3COK Chain A
Serine/threonine-protein kinase PLK4 (PLK4)
Inactive — 1.3%DFG-inαC-inATPlike · ANP
Resolution
2.25 Å
R-value
0.211
Predicted activity confidence1.3%
Structure info
Alternate conformationA
Missing atoms12
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SLATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKESDVWSLGCMFYTLLIGRPPFDTDTVKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS
UniProt reference sequence
FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM
Aligned reference sequence
FKVG----------------NLLGKGS----------------FAGVYRAES--IH------------------------------------TGLEVAIKMID--KKAMYKAGM-------------------------VQRVQNEVKIHCQL--------------------------KHPSILELYNYFEDSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVYLVLEMCHN--------------GEMNRYLKN--RVK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFSENEARHFMHQIITGMLYLHSH---------------------------------------------GILHRDL-----TLSNLLLTR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMNIKIADFGLATQLKMPHEK--H---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTLCGTPNYISPEIATR--------------------------------SAHG-LESDVWSLGCMFYTLLIG-----------------RPPFDT--------------------------------------------------DTVKNTLNKVVLA--DYEMPSFLS------------------------------------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS--------------LSSVLDHPFM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKVG----------------NLLGKGS----------------FAGVYRAES--IH------------------------------------TGLEVAIKMID--KKAMYKAGM-------------------------VQRVQNEVKIHCQL--------------------------KHPSILELYNYFEDSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVYLVLEMCHN--------------GEMNRYLKN--RVK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFSENEARHFMHQIITGMLYLHSH---------------------------------------------GILHRDL-----TLSNLLLTR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMNIKIADFGLATQLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESDVWSLGCMFYTLLIG-----------------RPPFDT--------------------------------------------------DTV-----KVVLA--DYEMPSFLS------------------------------------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS--------------LSSVLDHPFM
Activation segment
DFGLATQLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
NLLGKGSFAGVYRVAIKMIRVQNEVKIHCQLKPSILELYNYYLVLEMCHNGEMNRYLKNYLHSHGILHRDLTLSNLLLIADFGLA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3COK, Chain A