3CJF Chain A
Vascular endothelial growth factor receptor 2 (KDR)
Inactive — 0.5%DFG-outαC-inType1 · SAV
Resolution
2.15 Å
R-value
0.205
Predicted activity confidence0.5%
Structure info
Alternate conformationA
Missing atoms12
Missing residues4
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
CERLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKKDFLTLEHLIYSFQVAKGMEFLASRKIHRDLAARNILLSEKNVVKIDLARDIYKPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANA
UniProt reference sequence
LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGN
Aligned reference sequence
LKLG----------------KPLGRGA----------------FGQVIEADA--FGIDKTA-------------------------------TCRTVAVKMLK--EGATHSE---------------------------HRALMSELKILIHI--G-----------------------HHLNVVNLLGACTKPG--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLMVIVEFCKF--------------GNLSTYLRS--KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTLEHLICYSFQVAKGMEFLASR---------------------------------------------KCIHRDL-----AARNILLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVVKICDFGLARDIYKDPDY--VRK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDARLPLKWMAPETIFD--------------------------------RVYT-IQSDVWSFGVLLWEIFSL--G--------------ASPYPG--V-----------------------------------------------KIDEEFCRRLKEG--TRMRAPDYTT-----------------------------------------------------------------------------------------------------PEMYQTMLDCWHGEPSQRPT--------------FSELVEHLGN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LNLG----------------KPLGRGA----------------FGQVIEADA--FGIDKTA-------------------------------T-RTVAVKMLK--EGATHSE---------------------------HRALMSELKILIHI--G-----------------------HHLNVVNLLGACTKPG--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLMVIVEFCKF--------------GNLSTYLRS--KRNEFVPYK---------------------------------------------------------KD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTLEHLI-YSFQVAKGMEFLASR---------------------------------------------K-IHRDL-----AARNILLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVVKI---DLARDIYK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLKWMAPETIFD--------------------------------RVYT-IQSDVWSFGVLLWEIFSL--G--------------ASPYPG--V-----------------------------------------------KIDEEF-RRLKEG--TRMRAPDYTT-----------------------------------------------------------------------------------------------------PEMYQTMLDCWHGEPSQRPT--------------FSELVEHLGN
Activation segment
--DLARDIYK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLKWMAPE
Binding pocket
KPLGRGAFGQVIEVAVKMLALMSELKILIHIGLNVVNLLGAMVIVEFCKFGNLSTYLRSFLASRK_IHRDLAARNILLI_D__LA
Ligand info
Orthosteric ligand
SAV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3CJF, Chain A