3CEK Chain A
Dual specificity protein kinase TTK (TTK)
Inactive — 0.1%DFG-inαC-in
Resolution
2.3 Å
R-value
0.188
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
FQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQGTVNYMPPEAIKDMSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ
UniProt reference sequence
YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV
Aligned reference sequence
YSIL----------------KQIGSGG----------------SSKVFQVLN--E-------------------------------------KKQIYAIKYVN--LEEADNQT--------------------------LDSYRNEIAYLNKL--QQ----------------------HSDKIIRLYDYEITDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIYMVMECGN---------------IDLNSWLKK--KK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIDPWERKSYWKNMLEAVHTIHQH---------------------------------------------GIVHSDL-----KPANFLIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGMLKLIDFGIANQMQPDTTS--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSQVGTVNYMPPEAIKD--MSSSRENGKSK-------------------SKIS-PKSDVWSLGCILYYMTYG-----------------KTPFQQ--I-----------------------------------------------INQISKLHAIIDP--NHEIEFPDIPE----------------------------------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS--------------IPELLAHPYV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSIL----------------KQIGSGG----------------SSKVFQVLN--E-------------------------------------KKQIYAIKYVN--LEEADNQT--------------------------LDSYRNEIAYLNKL--QQ----------------------HSDKIIRLYDYEITDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIYMVMECGN---------------IDLNSWLKK--KK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIDPWERKSYWKNMLEAVHTIHQH---------------------------------------------GIVHSDL-----KPANFLIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGMLKLIDFGIANQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVNYMPPEAIKD--M-----------------------------SKIS-PKSDVWSLGCILYYMTYG-----------------KTPFQQ--I-----------------------------------------------INQISKLHAIIDP--NHEIEFPDIPE----------------------------------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS--------------IPELLAHPYV
Activation segment
DFGIANQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVNYMPPE
Binding pocket
KQIGSGGSSKVFQYAIKYVSYRNEIAYLNKLQDKIIRLYDYYMVMECGN_IDLNSWLKKTIHQHGIVHSDLKPANFLILIDFGIA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3CEK, Chain A