3CBL Chain A
Tyrosine-protein kinase Fes/Fps (FES)
Active — 100.0%DFG-inαC-inType1,Allosteric,Allosteric · STU
Resolution
1.75 Å
R-value
0.183
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH
UniProt reference sequence
LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQS
Aligned reference sequence
LVLG----------------EQIGRGN----------------FGEVFSGRL--RA------------------------------------DNTLVAVKSCR--ETLPPDL---------------------------KAKFLQEARILKQY--------------------------SHPNIVRLIGVCTQKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVMELVQG--------------GDFLTFLRT--EGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLRVKTLLQMVGDAAAGMEYLESK---------------------------------------------CCIHRDL-----AARNCLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVLKISDFGMSREEADGVYA--ASG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRQVPVKWTAPEALNY--------------------------------GRYS-SESDVWSFGILLWETFSL--G--------------ASPYPN--------------------------------------------------LSNQQTREFVEKG--GRLPCPELCP-----------------------------------------------------------------------------------------------------DAVFRLMEQCWAYEPGQRPS--------------FSTIYQELQS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------EQIGRGN----------------FGEVFSGRL--RA------------------------------------DNTLVAVKSCR--ETLPPDL---------------------------KAKFLQEARILKQY--------------------------SHPNIVRLIGVCTQKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVMELVQG--------------GDFLTFLRT--EGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLRVKTLLQMVGDAAAGMEYLESK---------------------------------------------CCIHRDL-----AARNCLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVLKISDFGMSREEADGVYA--ASG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRQVPVKWTAPEALNY--------------------------------GRYS-SESDVWSFGILLWETFSL--G--------------ASPYPN--------------------------------------------------LSNQQTREFVEKG--GRLPCPELCP-----------------------------------------------------------------------------------------------------DAVFRLMEQCWAYEPGQRPS--------------FSTIYQELQS
Activation segment
DFGMSREEADGVYA--ASG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRQVPVKWTAPE
Binding pocket
EQIGRGNFGEVFSVAVKSCKFLQEARILKQYSPNIVRLIGVYIVMELVQGGDFLTFLRTYLESKCCIHRDLAARNCLVISDFGMS
Ligand info
Orthosteric ligand
STU
Allosteric ligand
STU
Ligand typeType1,Allosteric,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3CBL, Chain A