3BV3 Chain A
Mitogen-activated protein kinase 14 (MAPK14)
Inactive — 0.0%DFG-outαC-inType2 · P39
Resolution
2.59 Å
R-value
0.198
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP
UniProt reference sequence
YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
Aligned reference sequence
YQNL----------------SPVGSGA----------------YGSVCAAFD--TK------------------------------------TGLRVAVKKLS--RPFQSIIH--------------------------AKRTYRELRLLKHM--------------------------KHENVIGLLDVFTPAR--SLEEFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVTHLMG---------------ADLNNIVKC--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA---------------------------------------------DIIHRDL-----KPSNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLARHTDDEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVATRWYRAPEIMLN--W-----------------------------MHYN-QTVDIWSVGCIMAELLTG-----------------RTLFPG--------------------------------------------------TDHIDQLKLILRL--VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----------------------------------------------------------------------PLAVDLLEKMLVLDSDKRIT--------------AAQALAHAYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQNL----------------SPVGSGA----------------YGSVCAAFD--TK------------------------------------TGLRVAVKKLS--RPFQSIIH--------------------------AKRTYRELRLLKHM--------------------------KHENVIGLLDVFTPAR--SLEEFN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVTHLMG---------------ADLNNIVKC--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA---------------------------------------------DIIHRDL-----KPSNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVATRWYRAPEIMLN--W-----------------------------MHYN-QTVDIWSVGCIMAELLTG-----------------RTLFPG--------------------------------------------------TDHIDQLKLILRL--VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----------------------------------------------------------------------PLAVDLLEKMLVLDSDKRIT--------------AAQALAHAYF
Activation segment
DFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVATRWYRAPE
Binding pocket
SPVGSGAYGSVCAVAVKKLRTYRELRLLKHMKENVIGLLDVYLVTHLMG_ADLNNIVKCYIHSADIIHRDLKPSNLAVILDFGL_
Ligand info
Orthosteric ligand
P39
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3BV3, Chain A