3BU5 Chain A
Insulin receptor (INSR)
Active — 98.5%DFG-inαC-inATPlike · ATP
Resolution
2.1 Å
R-value
0.196
Predicted activity confidence98.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DEWEVSREKITLLRELGQGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIETDRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK
UniProt reference sequence
ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD
Aligned reference sequence
ITLL----------------RELGQGS----------------FGMVYEGNA--RDIIKGE-------------------------------AETRVAVKTVN--ESASLRE---------------------------RIEFLNEASVMKGF--------------------------TCHHVVRLLGVVSKGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVVMELMAH--------------GDLKSYLRS--LRPEAENNPGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTLQEMIQMAAEIADGMAYLNAK---------------------------------------------KFVHRDL-----AARNCMVAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMAPESLKD--------------------------------GVFT-TSSDMWSFGVVLWEITSL--A--------------EQPYQG--------------------------------------------------LSNEQVLKFVMDG--GYLDQPDNCP-----------------------------------------------------------------------------------------------------ERVTDLMRMCWQFNPKMRPT--------------FLEIVNLLKD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------RELGQ-------------------GMVYEGNA--RDIIKGE-------------------------------AETRVAVKTVN--ESASLRE---------------------------RIEFLNEASVMKGF--------------------------TCHHVVRLLGVVSKGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVVMELMAH--------------GDLKSYLRS--LRPEAENNPGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTLQEMIQMAAEIADGMAYLNAK---------------------------------------------KFVHRDL-----AARNCMVAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDI-ETD----RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMAPESLKD--------------------------------GVFT-TSSDMWSFGVVLWEITSL--A--------------EQPYQG--------------------------------------------------LSNEQVLKFVMDG--GYLDQPDNCP-----------------------------------------------------------------------------------------------------ERVTDLMRMCWQFNPNMRPT--------------FLEIVNLLKD
Activation segment
DFGMTRDI-ETD----RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMAPE
Binding pocket
RELGQG___MVYEVAVKTVEFLNEASVMKGFT_HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGDFGMT
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3BU5, Chain A