3BLQ Chain A
Cyclin-dependent kinase 9 (CDK9)
Active — 99.4%DFG-inαC-inATPlike · ATP
Resolution
2.9 Å
R-value
0.174
Predicted activity confidence99.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSNRYNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLK
UniProt reference sequence
YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
Aligned reference sequence
YEKL----------------AKIGQGT----------------FGEVFKARH--RK------------------------------------TGQKVALKKVL--MENEKEGF--------------------------PITALREIKILQLL--------------------------KHENVVNLIEICRTKA--SPYNRCKG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIYLVFDFCE---------------HDLAGLLSN--VLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTLSEIKRVMQMLLNGLYYIHRN---------------------------------------------KILHRDM-----KAANVLITR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKLADFGLARAFSLAKNS--QPNRY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNRVVTLWYRPPELLLG--E-----------------------------RDYG-PPIDLWGAGCIMAEMWTR-----------------SPIMQG--------------------------------------------------NTEQHQLALISQL--CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD----------------------------------------------------------------------PYALDLIDKLLVLDPAQRID--------------SDDALNHDFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEKL----------------AKIGQGT----------------FGEVFKARH--RK------------------------------------TGQKVALKKVL--MENEKEGF--------------------------PITALREIKILQLL--------------------------KHENVVNLIEICRT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIYLVFDFCE---------------HDLAGLLSN--VLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTLSEIKRVMQMLLNGLYYIHRN---------------------------------------------KILHRDM-----KAANVLITR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGVLKLADFGLARAFS---------NRY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRVVTLWYRPPELLLG--E-----------------------------RDYG-PPIDLWGAGCIMAEMWTR-----------------SPIMQG--------------------------------------------------NTEQHQLALISQL--CGSITPEVWPNVDNYELYEKLELV------VKDRLKAYVRD----------------------------------------------------------------------PYALDLIDKLLVLDPAQRID--------------SDDALNHDFF
Activation segment
DFGLARAFS---------NRY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRVVTLWYRPPE
Binding pocket
AKIGQGTFGEVFKVALKKVTALREIKILQLLKENVVNLIEIYLVFDFCE_HDLAGLLSNYIHRNKILHRDMKAANVLILADFGLA
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3BLQ, Chain A