3BHH Chain B
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
Active — 100.0%DFG-inαC-inType1 · 5CP
Resolution
2.4 Å
R-value
0.225
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms21
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MTDEYQLYEDIGKSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLK
UniProt reference sequence
YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV
Aligned reference sequence
YQLY----------------EDIGKGA----------------FSVVRRCVK--LC------------------------------------TGHEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHSNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHYLVFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILEAVLHCHQM---------------------------------------------GVVHRDL-----KPENLLLAS--KCK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVQGDQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------EAYG-KPVDIWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHKLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKNLINQMLTINPAKRIT--------------AHEALKHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLY----------------EDIGK-------------------SVVRRCVK--LC------------------------------------TGHEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHSNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHYLVFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILEAVLHCHQM---------------------------------------------GVVHRDL-----KPENLLLAS--KCK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVQGDQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------EAYG-KPVDIWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHKLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKNLINQMLTINPAKRIT--------------AHEALKHPWV
Activation segment
DFGLAIEVQGDQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPE
Binding pocket
EDIGK___SVVRRYAAKIIKLEREARICRLLKSNIVRLHDSYLVFDLVTGGELFEDIVAHCHQMGVVHRDLKPENLLLLADFGLA
Ligand info
Orthosteric ligand
5CP
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3BHH, Chain B