3BCE Chain C
Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Active — 70.8%DFG-inαC-in
Resolution
2.5 Å
R-value
0.198
Predicted activity confidence70.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEDEKEYNADGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGD
UniProt reference sequence
LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSR
Aligned reference sequence
LKRV----------------KVLGSGA----------------FGTVYKGIW--VPEGET--------------------------------VKIPVAIKILN--ETTGPKA---------------------------NVEFMDEALIMASM--------------------------DHPHLVRLLGVCLSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIQLVTQLMPH--------------GCLLEYVHE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQLLLNWCVQIAKGMMYLEER---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLEGDEKE--YNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKMPIKWMALECIHY--------------------------------RKFT-HQSDVWSYGVTIWELMTF--G--------------GKPYDG--------------------------------------------------IPTREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK--------------FKELAAEFSR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKRV----------------KVLGSGA----------------FGTVYKGIW--VPEGET--------------------------------VKIPVAIKILN--ETTGPKA---------------------------NVEFMDEALIMASM--------------------------DHPHLVRLLGVCLSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIQLVTQLMPH--------------GCLLEYVHE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQLLLNWCVQIAKGMMYLEER---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLE-DEKE--YNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-GKMPIKWMALECIHY--------------------------------RKFT-HQSDVWSYGVTIWELMTF--G--------------GKPYDG--------------------------------------------------IPTREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK--------------FKELAAEFSR
Activation segment
DFGLARLLE-DEKE--YNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-GKMPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKILEFMDEALIMASMDPHLVRLLGVQLVTQLMPHGCLLEYVHEYLEERRLVHRDLAARNVLVITDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3BCE, Chain C