3BBW Chain A
Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Inactive — 0.2%DFG-inαC-out
Resolution
4.0 Å
R-value
0.305
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
AQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNEGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDD
UniProt reference sequence
LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSR
Aligned reference sequence
LKRV----------------KVLGSGA----------------FGTVYKGIW--VPEGET--------------------------------VKIPVAIKILN--ETTGPKA---------------------------NVEFMDEALIMASM--------------------------DHPHLVRLLGVCLSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIQLVTQLMPH--------------GCLLEYVHE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQLLLNWCVQIAKGMMYLEER---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLEGDEKE--YNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKMPIKWMALECIHY--------------------------------RKFT-HQSDVWSYGVTIWELMTF--G--------------GKPYDG--------------------------------------------------IPTREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK--------------FKELAAEFSR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKRV----------------KVLGSGA----------------FGTVYKGIW--VPEGET--------------------------------VKIPVAIKILN--E--GPKA---------------------------NVEFMDEALIMASM--------------------------DHPHLVRLLGVCLSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIQLVTQLMPH--------------GCLLEYVHE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQLLLNWCVQIAKGMMYLEER---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIKWMALECIHY--------------------------------RKFT-HQSDVWSYGVTIWELMTF--G--------------GKPYDG--------------------------------------------------IPTREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK--------------FKELAAEFSR
Activation segment
DFGLARLL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKILEFMDEALIMASMDPHLVRLLGVQLVTQLMPHGCLLEYVHEYLEERRLVHRDLAARNVLVITDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3BBW, Chain A