3AQV Chain A
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
Inactive — 0.9%DFG-outαC-outType1 · TAK
Resolution
2.08 Å
R-value
0.224
Predicted activity confidence0.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE
UniProt reference sequence
YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
Aligned reference sequence
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Activation segment
DFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNYAAPE
Binding pocket
DTLGVGTFGKVKIVAVKILKIKREIQNLKLFRPHIIKLYQVFMVMEYVSGGELFDYICKYCHRHMVVHRDLKPENVLLIADFGLS
Ligand info
Orthosteric ligand
TAK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3AQV, Chain A