3AOX Chain A
ALK tyrosine kinase receptor (ALK)
Inactive — 4.7%DFG-inαC-inType1 · EMH
Resolution
1.75 Å
R-value
0.17
Predicted activity confidence4.7%
Structure info
Alternate conformationB
Missing atoms0
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
STIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGGEVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRACAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEY
UniProt reference sequence
ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
Aligned reference sequence
ITLI----------------RGLGHGA----------------FGEVYEGQV--SGMPNDP-------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRASYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLI----------------RGLG--------------------GEVYEGQV----------------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Activation segment
DFGMARDIYRA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAMLPVKWMPPE
Binding pocket
RGLG____GEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA
Ligand info
Orthosteric ligand
EMH
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3AOX, Chain A