3ALN Chain C
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Inactive — 1.0%DFG-inαC-outATPlike · ANP
Resolution
2.3 Å
R-value
0.289
Predicted activity confidence1.0%
Structure info
Alternate conformation—
Missing atoms17
Missing residues32
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
EDLKDLGENKMVIMAVKRIRSTCPYIVQFYCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKKPSNILLDRSGNIKLCDFSDVWSLGITLYELATGRFPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPA
UniProt reference sequence
LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
Aligned reference sequence
LKDL----------------GEIGRGA----------------YGSVNKMVH--KP------------------------------------SGQIMAVKRIR--STVDEKE---------------------------QKQLLMDLDVVMRS--S-----------------------DCPYIVQFYGALFREG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCWICMELMS---------------TSFDKFYKY--VYSVLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIPEEILGKITLATVKALNHLKEN--L------------------------------------------KIIHRDI-----KPSNILLDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGNIKLCDFGISGQLVDSIAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRDAGCRPYMAPERIDP--SASR--------------------------QGYD-VRSDVWSLGITLYELATG-----------------RFPYPK--W-----------------------------------------------NSVFDQLTQVVKG--DPPQLSNSEEREFS-------------------------------------------------------------------------------------------------PSFINFVNLCLTKDESKRPK--------------YKELLKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKDL----------------GE-------------------------NKMV--------------------------------------------IMAVKRIR--ST-------------------------------------------------------------------------CPYIVQFY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CWICMELMS---------------TSFDKFYKY--VYSVLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIPEEILGKITLATVKALNHLKEN--L------------------------------------------K-----------KPSNILLDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGNIKLCDF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDVWSLGITLYELATG-----------------RF----------------------------------------------------------------------PPQLSNSEEREFS-------------------------------------------------------------------------------------------------PSFINFVNLCLTKDESKRPK--------------YKELLKHPFI
Activation segment
DF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
GE_________NKMAVKRI_____________PYIVQFY__WICMELMS_TSFDKFYKYLKENLK______KPSNILLLCDF__S
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3ALN, Chain C