3ALN Chain A
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
Inactive — 2.5%DFG-inαC-outATPlike · ANP
Resolution
2.3 Å
R-value
0.289
Predicted activity confidence2.5%
Structure info
Alternate conformation—
Missing atoms3
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
SSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQYDVRSDVWSLGITLYELATGRFPYPKWTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMP
UniProt reference sequence
LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
Aligned reference sequence
LKDL----------------GEIGRGA----------------YGSVNKMVH--KP------------------------------------SGQIMAVKRIR--STVDEKE---------------------------QKQLLMDLDVVMRS--S-----------------------DCPYIVQFYGALFREG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCWICMELMS---------------TSFDKFYKY--VYSVLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIPEEILGKITLATVKALNHLKEN--L------------------------------------------KIIHRDI-----KPSNILLDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGNIKLCDFGISGQLVDSIAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRDAGCRPYMAPERIDP--SASR--------------------------QGYD-VRSDVWSLGITLYELATG-----------------RFPYPK--W-----------------------------------------------NSVFDQLTQVVKG--DPPQLSNSEEREFS-------------------------------------------------------------------------------------------------PSFINFVNLCLTKDESKRPK--------------YKELLKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKDL----------------GEIGRGA----------------YGSVNKMVH--KP------------------------------------SGQIMAVKRIR--STVDEKE---------------------------QKQLLMDLDVVMRS--S-----------------------DCPYIVQFYGALFREG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCWICMELMS---------------TSFDKFYKY--VYSVLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIPEEILGKITLATVKALNHLKEN--L------------------------------------------KIIHRDI-----KPSNILLDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGNIKLCDFGISGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YD-VRSDVWSLGITLYELATG-----------------RFPYPK--W------------------------------------------------------TQVVKG--DPPQLSNSEEREFS-------------------------------------------------------------------------------------------------PSFINFVNLCLTKDESKRPK--------------YKELLKHPFI
Activation segment
DFGISGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
GEIGRGAYGSVNKMAVKRIQLLMDLDVVMRSSPYIVQFYGAWICMELMS_TSFDKFYKYLKENLKIIHRDIKPSNILLLCDFGIS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3ALN, Chain A