3A4O Chain X
Tyrosine-protein kinase Lyn (LYN)
Inactive — 1.9%DFG-inαC-inType1 · STU
Resolution
3.0 Å
R-value
0.293
Predicted activity confidence1.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVEGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATE
UniProt reference sequence
IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD
Aligned reference sequence
IKLV----------------KRLGAGQ----------------FGEVWMGYY--N-------------------------------------NSTKVAVKTLK--PGTMS-----------------------------VQAFLEEANLMKTL--------------------------QHDKLVRLYAVVTREE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYMAK--------------GSLLDFLKS--DEGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVLLPKLIDFSAQIAEGMAYIERK---------------------------------------------NYIHRDL-----RAANVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLMCKIADFGLARVIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GCFT-IKSDVWSFGILLYEIVTY--G--------------KIPYPG--------------------------------------------------RTNADVMTALSQG--YRMPRVENCP-----------------------------------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT--------------FDYLQSVLDD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKLV----------------KRLGAGQ----------------FGEVWMGYY--N-------------------------------------NSTKVAVKTLK--PGTMS-----------------------------VQAFLEEANLMKTL--------------------------QHDKLVRLYAVVTREE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYMAK--------------GSLLDFLKS--DEGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVLLPKLIDFSAQIAEGMAYIERK---------------------------------------------NYIHRDL-----RAANVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLMCKIADFGLARV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GCFT-IKSDVWSFGILLYEIVTY--G--------------KIPYPG--------------------------------------------------RTNADVMTALSQG--YRMPRVENCP-----------------------------------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT--------------FDYLQSVLDD
Activation segment
DFGLARV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPE
Binding pocket
KRLGAGQFGEVWMVAVKTLAFLEEANLMKTLQDKLVRLYAVYIITEYMAKGSLLDFLKSYIERKNYIHRDLRAANVLVIADFGLA
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3A4O, Chain X