2ZVA Chain A
Tyrosine-protein kinase Lyn (LYN)
Inactive — 25.8%DFG-inαC-inType1.5_Back · 1N1
Resolution
2.6 Å
R-value
0.199
Predicted activity confidence25.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIETAREGAKFPIKWTAPEAINFGCFTIKSNVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYT
UniProt reference sequence
IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD
Aligned reference sequence
IKLV----------------KRLGAGQ----------------FGEVWMGYY--N-------------------------------------NSTKVAVKTLK--PGTMS-----------------------------VQAFLEEANLMKTL--------------------------QHDKLVRLYAVVTREE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYMAK--------------GSLLDFLKS--DEGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVLLPKLIDFSAQIAEGMAYIERK---------------------------------------------NYIHRDL-----RAANVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLMCKIADFGLARVIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GCFT-IKSDVWSFGILLYEIVTY--G--------------KIPYPG--------------------------------------------------RTNADVMTALSQG--YRMPRVENCP-----------------------------------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT--------------FDYLQSVLDD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKLV----------------KKLGAGQ----------------FGEVWMGYY--N-------------------------------------NSTKVAVKTLK--PGTMS-----------------------------VQAFLEEANLMKTL--------------------------QHDKLVRLYAVVTKEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEFMAK--------------GSLLDFLKS--DEGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVLLPKLIDFSAQIAEGMAYIERK---------------------------------------------NYIHRDL-----RAANVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLMCKIADFGLARVIE----T--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GCFT-IKSNVWSFGILLYEIVTY--G--------------KIPYPG--------------------------------------------------RTNADVMSALSQG--YRMPRMENCP-----------------------------------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT--------------FDYLQSVLDD
Activation segment
DFGLARVIE----T--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPE
Binding pocket
KKLGAGQFGEVWMVAVKTLAFLEEANLMKTLQDKLVRLYAVYIITEFMAKGSLLDFLKSYIERKNYIHRDLRAANVLVIADFGLA
Ligand info
Orthosteric ligand
1N1
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2ZVA, Chain A