2ZV7 Chain A
Tyrosine-protein kinase Lyn (LYN)
Active — 81.8%DFG-inαC-in
Resolution
2.5 Å
R-value
0.206
Predicted activity confidence81.8%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIREGAKFPIKWTAPEAINFGCFTIKSNVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFY
UniProt reference sequence
IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD
Aligned reference sequence
IKLV----------------KRLGAGQ----------------FGEVWMGYY--N-------------------------------------NSTKVAVKTLK--PGTMS-----------------------------VQAFLEEANLMKTL--------------------------QHDKLVRLYAVVTREE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYMAK--------------GSLLDFLKS--DEGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVLLPKLIDFSAQIAEGMAYIERK---------------------------------------------NYIHRDL-----RAANVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLMCKIADFGLARVIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GCFT-IKSDVWSFGILLYEIVTY--G--------------KIPYPG--------------------------------------------------RTNADVMTALSQG--YRMPRVENCP-----------------------------------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT--------------FDYLQSVLDD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKLV----------------KKLGAGQ----------------FGEVWMGYY--N-------------------------------------NSTKVAVKTLK--PGTMS-----------------------------VQAFLEEANLMKTL--------------------------QHDKLVRLYAVVTKEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEFMAK--------------GSLLDFLKS--DEGG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVLLPKLIDFSAQIAEGMAYIERK---------------------------------------------NYIHRDL-----RAANVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLMCKIADFGLARVI---------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GCFT-IKSNVWSFGILLYEIVTY--G--------------KIPYPG--------------------------------------------------RTNADVMSALSQG--YRMPRMENCP-----------------------------------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT--------------FDYLQSVLDD
Activation segment
DFGLARVI---------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPE
Binding pocket
KKLGAGQFGEVWMVAVKTLAFLEEANLMKTLQDKLVRLYAVYIITEFMAKGSLLDFLKSYIERKNYIHRDLRAANVLVIADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2ZV7, Chain A