2Z7Q Chain A
Ribosomal protein S6 kinase alpha-1 (RPS6KA1)
Inactive — 0.0%DFG-inαC-outATPlike · ACP
Resolution
2.0 Å
R-value
0.264
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP
UniProt reference sequence
FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY
Aligned reference sequence
FELL----------------KVLGQGS----------------FGKVFLVRK--VTRPD---------------------------------SGHLYAMKVLK--KATLKVRD--------------------------RVRTKMERDILADV--------------------------NHPFVVKLHYAFQTEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILDFLRG--------------GDLFTRLSK--EV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSL---------------------------------------------GIIYRDL-----KPENILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDFGLSKEAIDHEKK--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSFCGTVEYMAPEVVNR--------------------------------QGHS-HSADWWSYGVLMFEMLTG-----------------SLPFQG--------------------------------------------------KDRKETMTLILKA--KLGMPQFLS------------------------------------------------------------------------------------------------------TEAQSLLRALFKRNPANRLG--SGPDG-------AEEIKRHVFY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELL----------------KVLGQGS----------------FGKVFLVRK--VTRPD---------------------------------SGHLYAMKVL----------------------------------------------ILADV--------------------------NHPFVVKLHYAFQTEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLILDFLRG--------------GDLFTRLSK--EV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSL---------------------------------------------GIIYRDL-----KPENILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDFGLSKE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVEYMAPEVVNR--------------------------------QGHS-HSADWWSYGVLMFEMLTG-----------------SLPFQG--------------------------------------------------KDRKETMTLILKA--KLGMPQFLS------------------------------------------------------------------------------------------------------TEAQSLLRALFKRNPANRLG--SGPDG-------AEEIKRHVFY
Activation segment
DFGLSKE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTVEYMAPE
Binding pocket
KVLGQGSFGKVFLYAMKVL_______ILADVNPFVVKLHYAYLILDFLRGGDLFTRLSKHLHSLGIIYRDLKPENILLLTDFGLS
Ligand info
Orthosteric ligand
ACP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2Z7Q, Chain A