2YAA Chain A
Death-associated protein kinase 2 (DAPK2)
Active — 99.9%DFG-inαC-inATPlike · ATP
Resolution
2.3 Å
R-value
0.219
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQQAMVRRESVVNLENFKKQYV
UniProt reference sequence
YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWI
Aligned reference sequence
YDIG----------------EELGSGQ----------------FAIVKKCRE--KS------------------------------------TGLEYAAKFIK--KRQSRASRRGVS----------------------REEIEREVSILRQV--------------------------LHHNVITLHDVYENRT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVLILELVSG--------------GELFDFLAQ--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSEEEATSFIKQILDGVNYLHTK---------------------------------------------KIAHFDL-----KPENIMLLD--KNIP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPHIKLIDFGLAHEIEDGVEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANITAV--SYDFDEEFFSQTS--------------------------------------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT--------------IQEALRHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDIG----------------EELGSGQ----------------FAIVKKCRE--KS------------------------------------TGLEYAAKFIK--KRQSRASRRGVC----------------------REEIEREVSILRQV--------------------------LHPNIITLHDVYENRT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVLILELVSG--------------GELFDFLAQ--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSEEEATSFIKQILDGVNYLHTK---------------------------------------------KIAHFDL-----KPENIMLLD--KNIP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPHIKLIDFGLAHEIEDGVEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANITAV--SYDFDEEFFSQTS--------------------------------------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT--------------IQEALRHPWI
Activation segment
DFGLAHEIEDGVEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPE
Binding pocket
EELGSGQFAIVKKYAAKFIEIEREVSILRQVLPNIITLHDVVLILELVSGGELFDFLAQYLHTKKIAHFDLKPENIMLLIDFGLA
Ligand info
Orthosteric ligand
ATP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2YAA, Chain A