2Y4P Chain D
Death-associated protein kinase 1 (DAPK1)
Inactive — 0.1%DFG-inαC-in
Resolution
2.65 Å
R-value
0.255
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms5
Missing residues22
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
VSREDIEREVSILKEIQHPNVITLHEVLELVAGGELFDFLAEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK
UniProt reference sequence
YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI
Aligned reference sequence
YDTG----------------EELGSGQ----------------FAVVKKCRE--KS------------------------------------TGLQYAAKFIK--KRRTKSSRRGVS----------------------REDIEREVSILKEI--------------------------QHPNVITLHEVYENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVILILELVAG--------------GELFDFLAE--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL---------------------------------------------QIAHFDL-----KPENIMLLD--RNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPRIKIIDFGLAHKIDFGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANVSAV--NYEFEDEYFSNTS--------------------------------------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT--------------IQDSLQHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
-------------------------------------------------------------------------------------------------------------------VS----------------------REDIEREVSILKEI--------------------------QHPNVITLHEV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LELVAG--------------GELFDFLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEEATEFLKQILNGVYYLHSL---------------------------------------------QIAHFDL-----KPENIMLLD--RNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPRIKIIDFGLAHKID-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANVSAV--NYEFEDEYFSNTS--------------------------------------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT--------------IQDSLQHPWI
Activation segment
DFGLAHKID-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEFVAPE
Binding pocket
___________________DIEREVSILKEIQPNVITLHEV___LELVAGGELFDFLAEYLHSLQIAHFDLKPENIMLIIDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2Y4P, Chain D