2Y4P Chain B
Death-associated protein kinase 1 (DAPK1)
Inactive — 0.6%DFG-inαC-in
Resolution
2.65 Å
R-value
0.255
Predicted activity confidence0.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues30
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
SREDIEREVSILKEIQHPNVITLGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLPRIKIIDFGLAHKIDPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI
UniProt reference sequence
YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI
Aligned reference sequence
YDTG----------------EELGSGQ----------------FAVVKKCRE--KS------------------------------------TGLQYAAKFIK--KRRTKSSRRGVS----------------------REDIEREVSILKEI--------------------------QHPNVITLHEVYENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVILILELVAG--------------GELFDFLAE--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL---------------------------------------------QIAHFDL-----KPENIMLLD--RNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPRIKIIDFGLAHKIDFGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANVSAV--NYEFEDEYFSNTS--------------------------------------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT--------------IQDSLQHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
--------------------------------------------------------------------------------------------------------------------S----------------------REDIEREVSILKEI--------------------------QHPNVITL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G--------------GELFDFLAE--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL---------------------------------------------QIAHFDL-----KPENIMLL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRIKIIDFGLAHKID-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANVSAV--NYEFEDEYFSNTS--------------------------------------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT--------------IQDSLQHPWI
Activation segment
DFGLAHKID-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEFVAPE
Binding pocket
___________________DIEREVSILKEIQPNVITL___________GGELFDFLAEYLHSLQIAHFDLKPENIMLIIDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2Y4P, Chain B