2XYU Chain A
Ephrin type-A receptor 4 (EPHA4)
Inactive — 0.0%DFG-inαC-inType1.5_Back · Q9G
Resolution
2.12 Å
R-value
0.192
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms2
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
FAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRT
UniProt reference sequence
IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDK
Aligned reference sequence
IKIE----------------KVIGVGE----------------FGEVCSGRL--KVPGK---------------------------------REICVAIKTLK--AGYTDKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIHLEGVVTKCK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEYMEN--------------GSLDAFLRK--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTVIQLVGMLRGIGSGMKYLSDM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGMSRVLEDDPEA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGKIPIRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------IALHQLMLDCWQKERSDRPK--------------FGQIVNMLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKIE----------------KVIGVGE----------------FGEVCSGRL--KVPGK---------------------------------REICVAIKTLK--AGYTDKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIHLEGVVTKCK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEYMEN--------------GSLDAFLRK--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTVIQLVGMLRGIGSGMKYLSDM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------IALHQLMLDCWQKERSDRPK--------------FGQIVNMLDK
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTAPE
Binding pocket
KVIGVGEFGEVCSVAIKTLDFLSEASIMGQFDPNIIHLEGVMIITEYMENGSLDAFLRKYLSDMSYVHRDLAARNILVVSDF___
Ligand info
Orthosteric ligand
Q9G
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2XYU, Chain A