2X7G Chain A
SRSF protein kinase 2 (SRPK2)
Active — 100.0%DFG-inαC-inType1 · PVB
Resolution
2.5 Å
R-value
0.186
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAELLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS
UniProt reference sequence
YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
Aligned reference sequence
YHVI----------------RKLGWGH----------------FSTVWLCWD--MQ------------------------------------GKRFVAMKVVK--SAQHY-----------------------------TETALDEIKLLKCV--RESDPSDP----------------NKDMVVQLIDDFKISG--MNGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCMVFEVLG---------------HHLLKWIIK--SNYQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPVRCVKSIIRQVLQGLDYLHSK--C------------------------------------------KIIHTDI-----KPENILMCV--DDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNAD--KIRVKIADLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSIEVLIG--------------------------------AGYS-TPADIWSTACMAFELATG-----------------DYLFEP--HSGEDY------------------------------------------SRDEDHIAHIIEL--LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDA------------------------------------------------------------AQFTDFLIPMLEMVPEKRAS--------------AGECLRHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YHVI----------------RKLGWGH----------------FSTVWLCWD--MQ------------------------------------GKRFVAMKVVK--SAQHY-----------------------------TETALDEIKLLKCV--RESDPSDP----------------NKDMVVQLIDDFKISG--MNGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCMVFEVLG---------------HHLLKWIIK--SNYQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPVRCVKSIIRQVLQGLDYLHSK--C------------------------------------------KIIHTDI-----KPENILMCV--DDAYVRRMAAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLVNPLDPRNAD--KIRVKIADLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSIEVLIG--------------------------------AGYS-TPADIWSTACMAFELATG-----------------DYLFEP--HSGEDY------------------------------------------SRDEDHIAHIIEL--LGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDA------------------------------------------------------------AQFTDFLIPMLEMVPEKRAS--------------AGECLRHPWL
Activation segment
DLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSIE
Binding pocket
RKLGWGHFSTVWLVAMKVVTALDEIKLLKCVRDMVVQLIDDCMVFEVLG_HHLLKWIIKLHSKCKIIHTDIKPENILMIADLGNA
Ligand info
Orthosteric ligand
PVB
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2X7G, Chain A