2X4F Chain A
Myosin light chain kinase family member 4 (MYLK4)
Active — 93.0%DFG-inαC-inType1 · 16X
Resolution
2.67 Å
R-value
0.193
Predicted activity confidence93.0%
Structure info
Alternate conformationB
Missing atoms8
Missing residues5
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLSAQ
UniProt reference sequence
YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL
Aligned reference sequence
YTVS--KT------------EILGGGR----------------FGQVHKCEE--TA------------------------------------TGLKLAAKIIK--TRGMKD----------------------------KEEVKNEISVMNQL--------------------------DHANLIQLYDAFESKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIVLVMEYVDG--------------GELFDRIID--ESY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLTELDTILFMKQICEGIRHMHQM---------------------------------------------YILHLDL-----KPENILCVN--RD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKQIKIIDFGLARRYKPREKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVNFGTPEFLAPEVVNY--------------------------------DFVS-FPTDMWSVGVIAYMLLSG-----------------LSPFLG--------------------------------------------------DNDAETLNNILAC--RWDLEDEEFQDIS--------------------------------------------------------------------------------------------------EEAKEFISKLLIKEKSWRIS--------------ASEALKHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTVS--KT------------EIL---------------------GQVHKCEE--TA------------------------------------TGLKLAAKIIK--TRGMKD----------------------------KEEVKNEISVMNQL--------------------------DHANLIQLYDAFESKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIVLVMEYVDG--------------GELFDRIID--ESY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLTELDTILFMKQICEGIRHMHQM---------------------------------------------YILHLDL-----KPENILCVN--RD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKQIKIIDFGLARRYKPREKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVNFGTPEFLAPEVVNY--------------------------------DFVS-FPTDMWSVGVIAYMLLSG-----------------LSPFLG--------------------------------------------------DNDAETLNNILAC--RWDLEDEEFQDIS--------------------------------------------------------------------------------------------------EEAKEFISKLLIKEKSWRIS--------------ASEALKHPWL
Activation segment
DFGLARRYKPREKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVNFGTPEFLAPE
Binding pocket
EILG_____QVHKLAAKIIEVKNEISVMNQLDANLIQLYDAVLVMEYVDGGELFDRIIDHMHQMYILHLDLKPENILCIIDFGLA
Ligand info
Orthosteric ligand
16X
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2X4F, Chain A