2WTK Chain C
Serine/threonine-protein kinase STK11 (STK11)
Active — 99.9%DFG-inαC-inATPlike · ANP
Resolution
2.65 Å
R-value
0.24
Predicted activity confidence99.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPEAPVPIPPSDRWTVVPYLE
UniProt reference sequence
YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF
Aligned reference sequence
YLMG----------------DLLGEGS----------------YGKVKEVLD--SE------------------------------------TLCRRAVKILK--KKKLRRIPNG------------------------EANVKKEIQLLRRL--------------------------RHKNVIQLVDVLYNEE--KQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMYMVMEYCV---------------CGMQEMLDS--VPEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFPVCQAHGYFCQLIDGLEYLHSQ---------------------------------------------GIVHKDI-----KPGNLLLTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTLKISDLGVAEALHPFAAD--DTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSQGSPAFQPPEIANG--L-----------------------------DTFSGFKVDIWSAGVTLYNITTG-----------------LYPFEG--------------------------------------------------DNIYKLFENIGKG--SYAIPGDCG------------------------------------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS--------------IRQIRQHSWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YLMG----------------DLLGEGS----------------YGKVKEVLD--SE------------------------------------TLCRRAVKILK--KKKLRRIPNG------------------------EANVKKEIQLLRRL--------------------------RHKNVIQLVDVLYNE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMYMVMEYCV---------------CGMQEMLDS--VPEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFPVCQAHGYFCQLIDGLEYLHSQ---------------------------------------------GIVHKDI-----KPGNLLLTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTLKISALGVAEALHPFAAD--DTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSQGSPAFQPPEIANG--L-----------------------------DTFSGFKVDIWSAGVTLYNITTG-----------------LYPFEG--------------------------------------------------DNIYKLFENIGKG--SYAIPGDCG------------------------------------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS--------------IRQIRQHSWF
Activation segment
ALGVAEALHPFAAD--DTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSQGSPAFQPPE
Binding pocket
DLLGEGSYGKVKERAVKILNVKKEIQLLRRLRKNVIQLVDVYMVMEYCVCGMQEMLDSVYLHSQGIVHKDIKPGNLLLISALGVA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2WTK, Chain C