2W4O Chain A
Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
Inactive — 0.1%DFG-inαC-outType1 · DKI
Resolution
2.17 Å
R-value
0.216
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms36
Missing residues7
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
IDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASS
UniProt reference sequence
FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
Aligned reference sequence
FEVE----------------SELGRGA----------------TSIVYRCKQ--KG------------------------------------TQKPYALKVLK--KTVD------------------------------KKIVRTEIGVLLRL--------------------------SHPNIIKLKEIFETPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EISLVLELVTG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSERDAADAVKQILEAVAYLHEN---------------------------------------------GIVHRDL-----KPENLLYAT--PAP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAPLKIADFGLSKIVEHQVLM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTVCGTPGYCAPEILRG--------------------------------CAYG-PEVDMWSVGIITYILLCG-----------------FEPFYD--E-----------------------------------------------RGDQFMFRRILNC--EYYFISPWWDEVS--------------------------------------------------------------------------------------------------LNAKDLVRKLIVLDPKKRLT--------------TFQALQHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEVE----------------SELGRGA----------------TSIVYRCKQ--KG------------------------------------TQKPYALKVLK--K----------------------------------------IGVLLRL--------------------------SHPNIIKLKEIFETPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EISLVLELVTG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSERDAADAVKQILEAVAYLHEN---------------------------------------------GIVHRDL-----KPENLLYAT--PAP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAPLKIADF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPGYCAPEILRG--------------------------------CAYG-PEVDMWSVGIITYILLCG-----------------FEPFYD--E-----------------------------------------------RGDQFMFRRILNC--EYYFISPWWDEVS--------------------------------------------------------------------------------------------------LNAKDLVRKLIVLDPKKRLT--------------TFQALQHPWV
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPGYCAPE
Binding pocket
SELGRGATSIVYRYALKVL_____IGVLLRLSPNIIKLKEISLVLELVTGGELFDRIVEYLHENGIVHRDLKPENLLYIADFG__
Ligand info
Orthosteric ligand
DKI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2W4O, Chain A