2VWW Chain A
Ephrin type-B receptor 4 (EPHB4)
Inactive — 0.0%DFG-inαC-inType1 · 7X2
Resolution
1.9 Å
R-value
0.186
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms4
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIV
UniProt reference sequence
VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDK
Aligned reference sequence
VKIE----------------EVIGAGE----------------FGEVCRGRL--KAPGK---------------------------------KESCVAIKTLK--GGYTERQ---------------------------RREFLSEASIMGQF--------------------------EHPNIIRLEGVVTNSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------GALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMRYLAEM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEENSSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIAF--------------------------------RKFT-SASDAWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPPDCP-----------------------------------------------------------------------------------------------------TSLHQLMLDCWQKDRNARPR--------------FPQVVSALDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------EVIGAGE----------------FGEVCRGRL--KAPGK---------------------------------KESCVAIKTL------TERQ---------------------------RREFLSEASIMGQF--------------------------EHPNIIRLEGVVTNSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------GALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMRYLAEM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTAPEAIAF--------------------------------RKFT-SASDAWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPPDCP-----------------------------------------------------------------------------------------------------TSLHQLMLDCWQKDRNARPR--------------FPQVVSALDK
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTAPE
Binding pocket
EVIGAGEFGEVCRVAIKTLEFLSEASIMGQFEPNIIRLEGVMILTEFMENGALDSFLRLYLAEMSYVHRDLAARNILVVSDF___
Ligand info
Orthosteric ligand
7X2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2VWW, Chain A