2VWI Chain D
Serine/threonine-protein kinase OSR1 (OXSR1)
Inactive — 0.0%DFG-inαC-outATPlike · ANP
Resolution
2.15 Å
R-value
0.253
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms2
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKE
UniProt reference sequence
YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
Aligned reference sequence
YELQ----------------EVIGSGA----------------TAVVQAAYC--AP------------------------------------KKEKVAIKRIN--LEKCQTS---------------------------MDELLKEIQAMSQC--------------------------HHPNIVSYYTSFVVKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWLVMKLLSG--------------GSVLDIIKH--IVAKGEHKSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN---------------------------------------------GQIHRDV-----KAGNILLGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVQIADFGVSAFLATGGDI--TRNKVR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFVGTPCWMAPEVMEQ--V-----------------------------RGYD-FKADIWSFGITAIELATG-----------------AAPYHK--------------------------------------------------YPPMKVLMLTLQN--DPPSLETGVQDKEMLKKYG--------------------------------------------------------------------------------------------KSFRKMISLCLQKDPEKRPT--------------AAELLRHKFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YELQ----------------EVIGSGA----------------TAVVQAAYC--AP------------------------------------KKEKVAIKRIN--LEKCQTS---------------------------MDELLKEIQAMSQC--------------------------HHPNIVSYYTSFVVKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWLVMKLLSG--------------GSVLDIIKH--IVAKGEHKSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN---------------------------------------------GQIHRDV-----KAGNILLGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVQIADFGVSAFLATGG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFVGTPCWMAPEVMEQ--V-----------------------------RGYD-FKADIWSFGITAIELATG-----------------AAPYHK--------------------------------------------------YPPMKVLMLTLQN--DPPSLETGVQDKEMLKKYG--------------------------------------------------------------------------------------------KSFRKMISLCLQKDPEKRPT--------------AAELLRHKFF
Activation segment
DFGVSAFLATGG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFVGTPCWMAPE
Binding pocket
EVIGSGATAVVQAVAIKRIELLKEIQAMSQCHPNIVSYYTSWLVMKLLSGGSVLDIIKHYLHKNGQIHRDVKAGNILLIADFGVS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2VWI, Chain D