2VD5 Chain A
Myotonin-protein kinase (DMPK)
Active — 98.6%DFG-inαC-inType1 · BI8
Resolution
2.8 Å
R-value
0.198
Predicted activity confidence98.6%
Structure info
Alternate conformation—
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDDTCNFDEDGLTAMVSGGGETLSDILGVHLPFVGYSYSCMALRDSEVP
UniProt reference sequence
FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFF
Aligned reference sequence
FEIL----------------KVIGRGA----------------FSEVAVVKM--KQ------------------------------------TGQVYAMKIMN--KWDMLKRGE-------------------------VSCFREERDVLVNG--------------------------DRRWITQLHFAFQDEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLVMEYYVG--------------GDLLTLLSK--FGE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIPAEMARFYLAEIVMAIDSVHRL---------------------------------------------GYVHRDI-----KPDNILLDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGHIRLADFGSCLKLRADGTV--RS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAVGTPDYLSPEILQA--VGGGPGT-----------------------GSYG-PECDWWALGVFAYEMFYG-----------------QTPFYA--------------------------------------------------DSTAETYGKIVHY--KEHLSLPLVDEGVP-------------------------------------------------------------------------------------------------EEARDFIQRLLC-PPETRLG--RGG---------AGDFRTHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEIL----------------KVIGRGA----------------FSEVAVVKM--KQ------------------------------------TGQVYAMKIMN--KWDMLKRGE-------------------------VSCFREERDVLVNG--------------------------DRRWITQLHFAFQDEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLVMEYYVG--------------GDLLTLLSK--FGE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIPAEMARFYLAEIVMAIDSVHRL---------------------------------------------GYVHRDI-----KPDNILLDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGHIRLADFGSCLKLRADGTV--RS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAVGTPDYLSPEILQA--VGGGPGT-----------------------GSYG-PECDWWALGVFAYEMFYG-----------------QTPFYA--------------------------------------------------DSTAETYGKIVHY--KEHLSLP----GVP-------------------------------------------------------------------------------------------------EEARDFIQRLLC-PPETRLG--RGG---------AGDFRTHPFF
Activation segment
DFGSCLKLRADGTV--RS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVAVGTPDYLSPE
Binding pocket
KVIGRGAFSEVAVYAMKIMCFREERDVLVNGDRWITQLHFAYLVMEYYVGGDLLTLLSKSVHRLGYVHRDIKPDNILLLADFGSC
Ligand info
Orthosteric ligand
BI8
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2VD5, Chain A