2V7O Chain A
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
Active — 99.6%DFG-inαC-in
Resolution
2.25 Å
R-value
0.179
Predicted activity confidence99.6%
Structure info
Alternate conformationA
Missing atoms16
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TENLYFQMATCTRFTDDYQLFEELGKGFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKG
UniProt reference sequence
YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV
Aligned reference sequence
YQLF----------------EELGKGA----------------FSVVRRCVK--KT------------------------------------STQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHYLVFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIHQILESVNHIHQH---------------------------------------------DIVHRDL-----KPENLLLAS--KCK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVQGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDIWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHKLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKNLINQMLTINPAKRIT--------------ADQALKHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLF----------------EELGKG-----------------FSVVRRCVK--KT------------------------------------PTQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHYLVFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIHQILESVNHIHQH---------------------------------------------DIVHRDL-----KPENLLLAS--KCK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVQGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDIWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHKLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKNLINQMLTINPAKRIT--------------ADQALKHPWV
Activation segment
DFGLAIEVQGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPE
Binding pocket
EELGKG_FSVVRRYAAKIIKLEREARICRLLKPNIVRLHDSYLVFDLVTGGELFEDIVAHIHQHDIVHRDLKPENLLLLADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2V7O, Chain A