2V62 Chain A
Serine/threonine-protein kinase VRK2 (VRK2)
Active — 100.0%DFG-inαC-in
Resolution
1.7 Å
R-value
0.203
Predicted activity confidence100.0%
Structure info
Alternate conformationA
Missing atoms18
Missing residues6
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
FPEGKVLDDMEGNQWVLGKKILIYLAFPTNKPEKDARHVVKVEYQEGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQ
UniProt reference sequence
WVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNP
Aligned reference sequence
WVLG----------------KKIGSGG----------------FGLIYLAFP--TNKPE---------------------------------KDARHVVKVEY--QE--------------------------------NGPLFSELKFYQRV--AKKDCIKKWIERKQLDY---------LGIPLFYGSGLTEF--KGRS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRFMVMERLG---------------IDLQKISGQ--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFKKSTVLQLGIRMLDVLEYIHEN---------------------------------------------EYVHGDI-----KAANLLLGY--KN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDQVYLADYGLSYRYCPNGNH--KQYQENPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHNGTIEFTSLDAHKG--------------------------------VALS-RRSDVEILGYCMLRWLCG-----------------KLPWEQ--NL----------------------------------------------KDPVAVQTAKTNL--LDELPQSVLKWAPSGSSC---------------------------------------------------------------------------------------------CEIAQFLVCAHSLAYDEKPN--------------YQALKKILNP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WVLG----------------KKI----------------------LIYLAFP--TNKPE---------------------------------KDARHVVKVEY--QE---------------------------------GPLFSELKFYQRV--AKKDCIKKWIERKQLDY---------LGIPLFYGSGLTEF--KGRS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRFMVMERLG---------------IDLQKISGQ--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFKKSTVLQLGIRMLDVLEYIHEN---------------------------------------------EYVHGDI-----KAANLLLGY--KN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDQVYLADYGLSYRYCPNGNH--KQYQENPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHNGTIEFTSLDAHKG--------------------------------VALS-RRSDVEILGYCMLRWLCG-----------------KLPWEQ--NL----------------------------------------------KDPVAVQTAKTNL--LDELPQSVLKWAPSGSSC---------------------------------------------------------------------------------------------CEIAQFLVCAHSLAYDEKPN--------------YQALKKILNP
Activation segment
DYGLSYRYCPNGNH--KQYQENPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGHNGTIEFTSLD
Binding pocket
KKI______LIYLHVVKVEPLFSELKFYQRVALGIPLFYGSFMVMERLG_IDLQKISGQYIHENEYVHGDIKAANLLLLADYGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2V62, Chain A