2UV2 Chain A
STE20-like serine/threonine-protein kinase (SLK)
Inactive — 11.0%DFG-inαC-inType1 · GVD
Resolution
2.3 Å
R-value
0.199
Predicted activity confidence11.0%
Structure info
Alternate conformationA
Missing atoms14
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YEHVTRDLNPEDFWEIIGELGDFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAK
UniProt reference sequence
WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
Aligned reference sequence
WEII----------------GELGDGA----------------FGKVYKAQN--KE------------------------------------TSVLAAAKVID--TKSEEE----------------------------LEDYMVEIDILASC--------------------------DHPNIVKLLDAFYYEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLWILIEFCAG--------------GAVDAVMLE--LER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN---------------------------------------------KIIHRDL-----KAGNILFTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGDIKLADFGVSAKNTRTIQR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPEVVMC--ETSKD-------------------------RPYD-YKADVWSLGITLIEMAEI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--EPPTLAQPSRWS---------------------------------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT--------------TSQLLQHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WEII----------------GELGD------------------FGKVYKAQN--KE------------------------------------TSVLAAAKVID--TKSEEE----------------------------LEDYMVEIDILASC--------------------------DHPNIVKLLDAFYYEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLWILIEFCAG--------------GAVDAVMLE--LER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN---------------------------------------------KIIHRDL-----KAGNILFTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGDIKLADFGVSAKNTRTIQR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPEVVMC--ETSKD-------------------------RPYD-YKADVWSLGITLIEMAEI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--EPPTLAQPSRWS---------------------------------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT--------------TSQLLQHPFV
Activation segment
DFGVSAKNTRTIQR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPE
Binding pocket
GELGD__FGKVYKAAAKVIDYMVEIDILASCDPNIVKLLDAWILIEFCAGGAVDAVMLEYLHDNKIIHRDLKAGNILFLADFGVS
Ligand info
Orthosteric ligand
GVD
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2UV2, Chain A