2R4B Chain B
Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Inactive — 0.0%DFG-inαC-outType1.5_Back · GW7
Resolution
2.4 Å
R-value
0.209
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms8
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDD
UniProt reference sequence
LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSR
Aligned reference sequence
LKRV----------------KVLGSGA----------------FGTVYKGIW--VPEGET--------------------------------VKIPVAIKILN--ETTGPKA---------------------------NVEFMDEALIMASM--------------------------DHPHLVRLLGVCLSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIQLVTQLMPH--------------GCLLEYVHE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQLLLNWCVQIAKGMMYLEER---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLEGDEKE--YNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKMPIKWMALECIHY--------------------------------RKFT-HQSDVWSYGVTIWELMTF--G--------------GKPYDG--------------------------------------------------IPTREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK--------------FKELAAEFSR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKRV----------------KVLGSGA----------------FGTVYKGIW--VPEGET--------------------------------VKIPVAIKIL---------A---------------------------NVEFMDEALIMASM--------------------------DHPHLVRLLGVCLSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIQLVTQLMPH--------------GCLLEYVHE--HKD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIGSQLLLNWCVQIAKGMMYLEER---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLEGDEKE--YNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKMPIKWMALECIHY--------------------------------RKFT-HQSDVWSYGVTIWELMTF--G--------------GKPYDG--------------------------------------------------IPTREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK--------------FKELAAEFSR
Activation segment
DFGLARLLEGDEKE--YNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKMPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKILEFMDEALIMASMDPHLVRLLGVQLVTQLMPHGCLLEYVHEYLEERRLVHRDLAARNVLVITDFGLA
Ligand info
Orthosteric ligand
GW7
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2R4B, Chain B