2R2P Chain A
Ephrin type-A receptor 5 (EPHA5)
Inactive — 11.3%DFG-inαC-in
Resolution
2.4 Å
R-value
0.203
Predicted activity confidence11.3%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPAAYTTRGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPAHHHHHH
UniProt reference sequence
ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDK
Aligned reference sequence
ITIE----------------RVIGAGE----------------FGEVCSGRL--KLPGK---------------------------------RELPVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIHLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDTFLKK--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGISAGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGKIPIRWTAPEAIAF--------------------------------RKFT-SASDVWSYGIVMWEVVSY--G--------------ERPYWE--------------------------------------------------MTNQDVIKAVEEG--YRLPSPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKERNSRPK--------------FDEIVNMLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITIE----------------RVIGAGE----------------FGEVCSGRL--KLPGK---------------------------------RELPVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIHLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDTFLKK--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGISAGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDP-A--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-GKIPIRWTAPEAIAF--------------------------------RKFT-SASDVWSYGIVMWEVVSY--G--------------ERPYWE--------------------------------------------------MTNQDVIKAVEEG--YRLPSPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKERNSRPK--------------FDEIVNMLDK
Activation segment
DFGLSRVLEDDP-A--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-GKIPIRWTAPE
Binding pocket
RVIGAGEFGEVCSVAIKTLDFLGEASIMGQFDPNIIHLEGVMIVTEYMENGSLDTFLKKYLSDMGYVHRDLAARNILIVSDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2R2P, Chain A