2QU5 Chain A
Vascular endothelial growth factor receptor 2 (KDR)
Inactive — 0.1%DFG-outαC-inType2 · 276
Resolution
2.95 Å
R-value
0.213
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
HAERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVITEFCKFGNLSTYLRSKRNEFVPYKVAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLADARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ
UniProt reference sequence
LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGN
Aligned reference sequence
LKLG----------------KPLGRGA----------------FGQVIEADA--FGIDKTA-------------------------------TCRTVAVKMLK--EGATHSE---------------------------HRALMSELKILIHI--G-----------------------HHLNVVNLLGACTKPG--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLMVIVEFCKF--------------GNLSTYLRS--KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTLEHLICYSFQVAKGMEFLASR---------------------------------------------KCIHRDL-----AARNILLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVVKICDFGLARDIYKDPDY--VRK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDARLPLKWMAPETIFD--------------------------------RVYT-IQSDVWSFGVLLWEIFSL--G--------------ASPYPG--V-----------------------------------------------KIDEEFCRRLKEG--TRMRAPDYTT-----------------------------------------------------------------------------------------------------PEMYQTMLDCWHGEPSQRPT--------------FSELVEHLGN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLG----------------KPLGRGA----------------FGQVIEADA--FGIDKTA-------------------------------TCRTVAVKMLK--EGATHSE---------------------------HRALMSELKILIHI--G-----------------------HHLNVVNLLGACTKPG--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLMVITEFCKF--------------GNLSTYLRS--KRNEFVPYK--------------------------------------------------VAPEDLYKD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTLEHLICYSFQVAKGMEFLASR---------------------------------------------KCIHRDL-----AARNILLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVVKICDFGLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DARLPLKWMAPETIFD--------------------------------RVYT-IQSDVWSFGVLLWEIFSL--G--------------ASPYPG--V-----------------------------------------------KIDEEFCRRLKEG--TRMRAPDYTT-----------------------------------------------------------------------------------------------------PEMYQTMLDCWHGEPSQRPT--------------FSELVEHLGN
Activation segment
DFGLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DARLPLKWMAPE
Binding pocket
KPLGRGAFGQVIEVAVKMLALMSELKILIHIGLNVVNLLGAMVITEFCKFGNLSTYLRSFLASRKCIHRDLAARNILLICDFGLA
Ligand info
Orthosteric ligand
276
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2QU5, Chain A