2QO7 Chain A
Ephrin type-A receptor 3 (EPHA3)
Inactive — 0.0%DFG-inαC-inATPlike · ANP
Resolution
1.6 Å
R-value
0.186
Predicted activity confidence0.0%
Structure info
Alternate conformationC
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TYVDPHTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSPSNLLLD
UniProt reference sequence
ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDK
Aligned reference sequence
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGKIPIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTE-MEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTSPE
Binding pocket
KVVGAGEFGEV_SVAIKTLDFLGEASIMGQ_DPNI_RLEGVMIVTE_M_NGSLDSFLRKYLSDMGYVHRDLAARNILIVSDFG__
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2QO7, Chain A