2QLU Chain A
Activin receptor type-2B (ACVR2B)
Active — 99.5%DFG-inαC-inType1 · ADE
Resolution
2.0 Å
R-value
0.219
Predicted activity confidence99.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GSLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS
UniProt reference sequence
LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
Aligned reference sequence
LQLL----------------EIKARGR----------------FGCVWKAQL----------------------------------------MNDFVAVKIFP--LQD-------------------------------KQSWQSEREIFSTP--GM----------------------KHENLLQFIAAEKRGS--NLEV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWLITAFHDK--------------GSLTDYLKG--N--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IITWNELCHVAETMSRGLSYLHED--VPWCRGEGHKP--------------------------------SIAHRDF-----KSKNVLLKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTAVLADFGLAVRFEPGKPP--GDT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGQVGTRRYMAPEVLEG--AINFQ-------------------------RDAF-LRIDMYAMGLVLWELVSR--CKAADGPVDEY----MLPFEE--EIGQH-------------------------------------------PSLEELQEVVVHK--KMRPTIKDHWLKHPGL-----------------------------------------------------------------------------------------------AQLCVTIEECWDHDAEARLS--------------AGCVEERVSL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQLL----------------EIKARGR----------------FGCVWKAQL----------------------------------------MNDFVAVKIFP--LQD-------------------------------KQSWQSEREIFSTP--GM----------------------KHENLLQFIAAEKRGS--NLEV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWLITAFHDK--------------GSLTDYLKG--N--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IITWNELCHVAETMSRGLSYLHED--VPWCRGEGHKP--------------------------------SIAHRDF-----KSKNVLLKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTAVLADFGLAVRFEPGKPP--GDT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGQVGTRRYMAPEVLEG--AINFQ-------------------------RDAF-LRIDMYAMGLVLWELVSR--CKAADGPVDEY----MLPFEE--EIGQH-------------------------------------------PSLEELQEVVVHK--KMRPTIKDHWLKHPGL-----------------------------------------------------------------------------------------------AQLCVTIEECWDHDAEARLS--------------AGCVEERVSL
Activation segment
DFGLAVRFEPGKPP--GDT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGQVGTRRYMAPE
Binding pocket
EIKARGRFGCVWKVAVKIFSWQSEREIFSTPGENLLQFIAAWLITAFHDKGSLTDYLKGEGHKPSIAHRDFKSKNVLLLADFGLA
Ligand info
Orthosteric ligand
ADE
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2QLU, Chain A