2P4I Chain B
Angiopoietin-1 receptor (TEK)
Inactive — 0.2%DFG-outαC-outType2 · MR9
Resolution
2.5 Å
R-value
0.248
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms27
Missing residues9
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GQVLKARIRMDAAIKRMKEKDDHRDFAGELEVLCKLGHHPNIINLLGACEHYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGID
UniProt reference sequence
IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR
Aligned reference sequence
IKFQ----------------DVIGEGN----------------FGQVLKARI--KKDG----------------------------------LRMDAAIKRMK--EYASKDD---------------------------HRDFAGELEVLCKL--G-----------------------HHPNIINLLGACEHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGLSRGQEVYVKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
--------------------------------------------GQVLKARI-----------------------------------------RMDAAIKRMK--E---KDD---------------------------HRDFAGELEVLCKL--G-----------------------HHPNIINLLGACEH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Activation segment
DFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVRWMAIE
Binding pocket
________GQVLKAAIKRMDFAGELEVLCKLGPNIINLLGAYLAIEYAPHGNLLDFLRKYLSQKQFIHRDLAARNILVIADFGL_
Ligand info
Orthosteric ligand
MR9
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2P4I, Chain B