2OZO Chain A
Tyrosine-protein kinase ZAP-70 (ZAP70)
Inactive — 0.0%DFG-inαC-outATPlike · ANP
Resolution
2.6 Å
R-value
0.26
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGGSALEVA
UniProt reference sequence
LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA
Aligned reference sequence
LLIA--D-------------IELGCGN----------------FGSVRQGVY--RMRK----------------------------------KQIDVAIKVLK--QGTEKAD---------------------------TEEMMREAQIMHQL--------------------------DNPYIVRLIGVCQAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALMLVMEMAGG--------------GPLHKFLVG--KRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIPVSNVAELLHQVSMGMKYLEEK---------------------------------------------NFVHRDL-----AARNVLLVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHYAKISDFGLSKALGADDSY--YTAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAGKWPLKWYAPECINF--------------------------------RKFS-SRSDVWSYGVTMWEALSY--G--------------QKPYKK--------------------------------------------------MKGPEVMAFIEQG--KRMECPPECP-----------------------------------------------------------------------------------------------------PELYALMSDCWIYKWEDRPD--------------FLTVEQRMRA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LLIA--D-------------IELGCGN----------------FGSVRQGVY--RMRK----------------------------------KQIDVAIKVLK--QGTEKAD---------------------------TEEMMREAQIMHQL--------------------------DNPYIVRLIGVCQAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALMLVMEMAGG--------------GPLHKFLVG--KRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIPVSNVAELLHQVSMGMKYLEEK---------------------------------------------NFVHRNL-----AARNVLLVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHYAKISDFGLSKALG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLKWYAPECINF--------------------------------RKFS-SRSDVWSYGVTMWEALSY--G--------------QKPYKK--------------------------------------------------MKGPEVMAFIEQG--KRMECPPECP-----------------------------------------------------------------------------------------------------PELYALMSDCWIYKWEDRPD--------------FLTVEQRMRA
Activation segment
DFGLSKALG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLKWYAPE
Binding pocket
IELGCGNFGSVRQVAIKVLEMMREAQIMHQLDPYIVRLIGVMLVMEMAGGGPLHKFLVGYLEEKNFVHRNLAARNVLLISDFGLS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2OZO, Chain A