2OO8 Chain X
Angiopoietin-1 receptor (TEK)
Inactive — 0.0%DFG-outαC-inType2 · RAJ
Resolution
2.2 Å
R-value
0.235
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms27
Missing residues9
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GQVLKARIRMDAAIKRMKEKDDHRDFAGELEVLCKLGHHPNIINLLGACEHYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGID
UniProt reference sequence
IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR
Aligned reference sequence
IKFQ----------------DVIGEGN----------------FGQVLKARI--KKDG----------------------------------LRMDAAIKRMK--EYASKDD---------------------------HRDFAGELEVLCKL--G-----------------------HHPNIINLLGACEHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGLSRGQEVYVKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
--------------------------------------------GQVLKARI-----------------------------------------RMDAAIKRMK--E---KDD---------------------------HRDFAGELEVLCKL--G-----------------------HHPNIINLLGACEH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Activation segment
DFGL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGRLPVRWMAIE
Binding pocket
________GQVLKAAIKRMDFAGELEVLCKLGPNIINLLGAYLAIEYAPHGNLLDFLRKYLSQKQFIHRDLAARNILVIADFGL_
Ligand info
Orthosteric ligand
RAJ
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2OO8, Chain X