2OGV Chain A
Macrophage colony-stimulating factor 1 receptor (CSF1R)
Inactive — 0.0%DFG-outαC-in
Resolution
2.7 Å
R-value
0.21
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
KPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDR
UniProt reference sequence
LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE
Aligned reference sequence
LQFG----------------KTLGAGA----------------FGKVVEATA--FGLGKED-------------------------------AVLKVAVKMLK--STAHADE---------------------------KEALMSELKIMSHL--G-----------------------QHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVLVITEYCCY--------------GDLLNFLRR--KAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLELRDLLHFSSQVAQGMAFLASK---------------------------------------------NCIHRDV-----AARNVLLTN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHVAKIGDFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFD--------------------------------CVYT-VQSDVWSYGILLWEIFSL--G--------------LNPYPG--I-----------------------------------------------LVNSKFYKLVKDG--YQMAQPAFAP-----------------------------------------------------------------------------------------------------KNIYSIMQACWALEPTHRPT--------------FQQICSFLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQFG----------------KTLGAGA----------------FGKVVEATA--FGLGKED-------------------------------AVLKVAVKMLK--STAHADE---------------------------KEALMSELKIMSHL--G-----------------------QHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVLVITEYCCY--------------GDLLNFLRR--KAEA-----------------------------------------------------------DLDKEDGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLELRDLLHFSSQVAQGMAFLASK---------------------------------------------NCIHRDV-----AARNVLLTN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHVAKIGDFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFD--------------------------------CVYT-VQSDVWSYGILLWEIFSL--G--------------LNPYPG--I-----------------------------------------------LVNSKFYKLVKDG--YQMAQPAFAP-----------------------------------------------------------------------------------------------------KNIYSIMQACWALEPTHRPT--------------FQQICSFLQE
Activation segment
DFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPE
Binding pocket
KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDVAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2OGV, Chain A