2O8Y Chain A
Interleukin-1 receptor-associated kinase 4 (IRAK4)
Active — 97.0%DFG-inαC-in
Resolution
2.4 Å
R-value
0.246
Predicted activity confidence97.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
FHSFSFYELKNVTNNFDERPISVGGNKGEGGFGVVYKGYVNNTTVAVKKLLKQQFDQEIKVAKCQHENLVELLGFSSDGDDLCLVYVYPNGSLLDRLSCLDGTPPLSWHRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASVSRIVGTTAYAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKNDADSTSVEAYSVASQCLHEKKNKRPDIKKVQQLLQETA
UniProt reference sequence
NVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE
Aligned reference sequence
NVT---NNFDERPISVGG--NKMGEGG----------------FGVVYKGYV----------------------------------------NNTTVAVKKLA--AMVDITTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARASEKFAQT--VMT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
NVT---NNFDERPISVGG--NK-GEGG----------------FGVVYKGYV----------------------------------------NNTTVAVKKL------------L------------------------KQQFDQEIKV-AKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVY-PN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWH-RCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARAS----------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIVGTTAY-APEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKK-NDADSTSV-------------------------------------------------------------------------------------------EA-YSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Activation segment
DFGLARAS----------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIVGTTAY-APE
Binding pocket
NKMGEGGFGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2O8Y, Chain A