2JFL Chain A
STE20-like serine/threonine-protein kinase (SLK)
Inactive — 0.7%DFG-inαC-inType1 · DKI
Resolution
2.2 Å
R-value
0.205
Predicted activity confidence0.7%
Structure info
Alternate conformation—
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
YEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRIQRRDFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAK
UniProt reference sequence
WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
Aligned reference sequence
WEII----------------GELGDGA----------------FGKVYKAQN--KE------------------------------------TSVLAAAKVID--TKSEEE----------------------------LEDYMVEIDILASC--------------------------DHPNIVKLLDAFYYEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLWILIEFCAG--------------GAVDAVMLE--LER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN---------------------------------------------KIIHRDL-----KAGNILFTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGDIKLADFGVSAKNTRTIQR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPEVVMC--ETSKD-------------------------RPYD-YKADVWSLGITLIEMAEI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--EPPTLAQPSRWS---------------------------------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT--------------TSQLLQHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WEII----------------GELGDGA----------------FGKVYKAQN--KE------------------------------------TSVLAAAKVID--TKSEEE----------------------------LEDYMVEIDILASC--------------------------DHPNIVKLLDAFYYEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLWILIEFCAG--------------GAVDAVMLE--LER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN---------------------------------------------KIIHRDL-----KAGNILFTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGDIKLADFGVSAKNTR-IQR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-FIGTPYWMAPEVVMC--ETSKD-------------------------RPYD-YKADVWSLGITLIEMAEI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--EPPTLAQPSRWS---------------------------------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT--------------TSQLLQHPFV
Activation segment
DFGVSAKNTR-IQR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-FIGTPYWMAPE
Binding pocket
GELGDGAFGKVYKAAAKVIDYMVEIDILASCDPNIVKLLDAWILIEFCAGGAVDAVMLEYLHDNKIIHRDLKAGNILFLADFGVS
Ligand info
Orthosteric ligand
DKI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2JFL, Chain A