2JC6 Chain C
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
Inactive — 0.1%DFG-outαC-outType1 · QPP
Resolution
2.3 Å
R-value
0.189
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms37
Missing residues5
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
SWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKASIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNAT
UniProt reference sequence
FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI
Aligned reference sequence
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKALKGK---------------------------ESSIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFGLSKMEGKGDVM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKA---------------------------------SIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMIS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Activation segment
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGYVAPE
Binding pocket
ETLGTGAFSEVVLFAVKCISIENEIAVLRKIKENIVALEDIYLVMQLVSGGELFDRIVEYLHRMGIVHRDLKPENLLYIS_____
Ligand info
Orthosteric ligand
QPP
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2JC6, Chain C