2JAM Chain A
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
Inactive — 0.2%DFG-inαC-outType1 · J60
Resolution
1.7 Å
R-value
0.157
Predicted activity confidence0.2%
Structure info
Alternate conformationB
Missing atoms5
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKS
UniProt reference sequence
FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI
Aligned reference sequence
FIFM----------------EVLGSGA----------------FSEVFLVKQ--RL------------------------------------TGKLFALKCIK--KSPAFR----------------------------DSSLENEIAVLKKI--------------------------KHENIVTLEDIYESTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYYLVMQLVSG--------------GELFDRILE--RG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYTEKDASLVIQQVLSAVKYLHEN---------------------------------------------GIVHRDL-----KPENLLYLT--PEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSKIMITDFGLSKMEQNGIM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVITYILLCG-----------------YPPFYE--------------------------------------------------ETESKLFEKIKEG--YYEFESPFWDDIS--------------------------------------------------------------------------------------------------ESAKDFICHLLEKDPNERYT--------------CEKALSHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FIFM----------------EVLGSGA----------------FSEVFLVKQ--RL------------------------------------TGKLFALKCIK--K----------------------------------SSLENEIAVLKKI--------------------------KHENIVTLEDIYESTT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYYLVMQLVSG--------------GELFDRILE--RG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYTEKDASLVIQQVLSAVKYLHEN---------------------------------------------GIVHRDL-----KPENLLYLT--PEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSKIMITDFGLSKMEQNGIM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVITYILLCG-----------------YPPFYE--------------------------------------------------ETESKLFEKIKEG--YYEFESPFWDDIS--------------------------------------------------------------------------------------------------ESAKDFICHLLEKDPNERYT--------------CEKALSHPWI
Activation segment
DFGLSKMEQNGIM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPE
Binding pocket
EVLGSGAFSEVFLFALKCISLENEIAVLKKIKENIVTLEDIYLVMQLVSGGELFDRILEYLHENGIVHRDLKPENLLYITDFGLS
Ligand info
Orthosteric ligand
J60
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2JAM, Chain A