2IZS Chain A
Casein kinase I isoform gamma-3 (CSNK1G3)
Active — 99.7%DFG-inαC-inType1 · BRQ
Resolution
1.95 Å
R-value
0.182
Predicted activity confidence99.7%
Structure info
Alternate conformationB
Missing atoms15
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTP
UniProt reference sequence
FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTD
Aligned reference sequence
FRVG----------------KKIGCGN----------------FGELRLGKN--LY------------------------------------TNEYVAIKLEP--MKSR------------------------------APQLHLEYRFYKQL--G-----------------------SGDGIPQVYYFGPCGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNAMVLELLG---------------PSLEDLFDL--CDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFSLKTVLMIAIQLISRMEYVHSK---------------------------------------------NLIYRDV-----KPENFLIGR--PGNKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQVIHIIDFGLAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLTGTARYMSINTHLG--------------------------------KEQS-RRDDLEALGHMFMYFLRG-----------------SLPWQG--LKADTLK-----------------------------------------ERYQKIGDTKRAT--PIEVLCENF------------------------------------------------------------------------------------------------------PEMATYLRYVRRLDFFEKPD--------------YDYLRKLFTD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FRVG----------------KKIGCGN----------------FGELRLGKN--LY------------------------------------TNEYVAIKLEP--MKSR------------------------------APQLHLEYRFYKQL--G-----------------------SGDGIPQVYYFGPCGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNAMVLELLG---------------PSLEDLFDL--CDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFSLKTVLMIAIQLISRMEYVHSK---------------------------------------------NLIYRDV-----KPENFLIGR--PGNKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQVIHIIDFALAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLTGTARYMSINTHLG--------------------------------KEQS-RRDDLEALGHMFMYFLRG-----------------SLPWQG--LKADTLK-----------------------------------------ERYQKIGDTKRAT--PIEVLCENF------------------------------------------------------------------------------------------------------PEMATYLRYVRRLDFFEKPD--------------YDYLRKLFTD
Activation segment
DFALAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLTGTARYMSIN
Binding pocket
KKIGCGNFGELRLVAIKLEQLHLEYRFYKQLGDGIPQVYYFAMVLELLG_PSLEDLFDLYVHSKNLIYRDVKPENFLIIIDFALA
Ligand info
Orthosteric ligand
BRQ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2IZS, Chain A