2IWI Chain A
Serine/threonine-protein kinase pim-2 (PIM2)
Active — 93.9%DFG-inαC-inType1 · HB1
Resolution
2.8 Å
R-value
0.244
Predicted activity confidence93.9%
Structure info
Alternate conformation—
Missing atoms28
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLVTCPLEVALLWKVGAGGGHPGVIRLLDWFFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQT
UniProt reference sequence
YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM
Aligned reference sequence
YRLG----------------PLLGKGG----------------FGTVFAGHR--LT------------------------------------DRLQVAIKVIP--RNRVLGWSPLSD----------------------SVTCPLEVALLWKV--GAGG--------------------GHPGVIRLLDWFETQE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFMLVLERPLP--A-----------QDLFDYITE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGEGPSRCFFGQVVAAIQHCHSR---------------------------------------------GVVHRDI-----KDENILIDL--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGCAKLIDFGSGALLHDEPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDFDGTRVYSPPEWISR--------------------------------HQYHALPATVWSLGILLYDMVCG-----------------DIPFE--------------------------------------------------------RDQEILEA--ELHFPAHVS------------------------------------------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS--------------LEEILLDPWM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLG----------------PLLGKGG----------------FGTVFAGHR--LT------------------------------------DRLQVAIKVIP--RNRVL------------------------------VTCPLEVALLWKV--GAGG--------------------GHPGVIRLLDWF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FMLVLERPLP--A-----------QDLFDYITE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGEGPSRCFFGQVVAAIQHCHSR---------------------------------------------GVVHRDI-----KDENILIDL--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGCAKLIDFGSGALLHDEPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDFDGTRVYSPPEWISR--------------------------------HQYHALPATVWSLGILLYDMVCG-----------------DIPFE--------------------------------------------------------RDQEILEA--ELHFPAHVS------------------------------------------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS--------------LEEILLDPWM
Activation segment
DFGSGALLHDEPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDFDGTRVYSPPE
Binding pocket
PLLGKGGFGTVFAVAIKVITCPLEVALLWKVGPGVIRLLDWMLVLERPLAQDLFDYITEHCHSRGVVHRDIKDENILILIDFGSG
Ligand info
Orthosteric ligand
HB1
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2IWI, Chain A