2I0E Chain B
Protein kinase C beta type (PRKCB)
Active — 98.4%DFG-inαC-inType1 · PDS
Resolution
2.6 Å
R-value
0.237
Predicted activity confidence98.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKAIDQSEFEGFFVNSEFLKP
UniProt reference sequence
FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
Aligned reference sequence
FNFL----------------MVLGKGS----------------FGKVMLSER--KG------------------------------------TDELYAVKILK--KDVVIQDDD-------------------------VECTMVEKRVLALP--G-----------------------KPPFLTQLHSCFQTMD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYFVMEYVNG--------------GDLMYHIQQ--VG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSK---------------------------------------------GIIYRDL-----KLDNVMLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKIADFGMCKENIWDGVT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFCGTPDYIAPEIIAY--------------------------------QPYG-KSVDWWAFGVLLYEMLAG-----------------QAPFEG--------------------------------------------------EDEDELFQSIMEH--NVAYPKSMS------------------------------------------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG--CGPEG-------ERDIKEHAFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FNFL----------------MVLGKGS----------------FGKVMLSER--KG------------------------------------TDELYAVKILK--KDVVIQDDD-------------------------VECTMVEKRVLALP--G-----------------------KPPFLTQLHSCFQTMD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYFVMEYVNG--------------GDLMYHIQQ--VG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSK---------------------------------------------GIIYRDL-----KLDNVMLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKIADFGMCKENIWDGVT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-FCGTPDYIAPEIIAY--------------------------------QPYG-KSVDWWAFGVLLYEMLAG-----------------QAPFEG--------------------------------------------------EDEDELFQSIMEH--NVAYPKSMS------------------------------------------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG--CGPEG-------ERDIKEHAFF
Activation segment
DFGMCKENIWDGVT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-FCGTPDYIAPE
Binding pocket
MVLGKGSFGKVMLYAVKILCTMVEKRVLALPGPFLTQLHSCYFVMEYVNGGDLMYHIQQFLQSKGIIYRDLKLDNVMLIADFGMC
Ligand info
Orthosteric ligand
PDS
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2I0E, Chain B