2HK5 Chain A
Tyrosine-protein kinase HCK (HCK)
Active — 99.9%DFG-inαC-inType1.5_Back · 1BM
Resolution
2.0 Å
R-value
0.201
Predicted activity confidence99.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDF
UniProt reference sequence
LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD
Aligned reference sequence
LKLE----------------KKLGAGQ----------------FGEVWMATY--N-------------------------------------KHTKVAVKTMK--PGSMS-----------------------------VEAFLAEANVMKTL--------------------------QHDKLVKLHAVVTKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEFMAK--------------GSLLDFLKS--DEGS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQPLPKLIDFSAQIAEGMAFIEQR---------------------------------------------NYIHRDL-----RAANILVSA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLVCKIADFGLARVIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GSFT-IKSDVWSFGILLMEIVTY--G--------------RIPYPG--------------------------------------------------MSNPEVIRALERG--YRMPRPENCP-----------------------------------------------------------------------------------------------------EELYNIMMRCWKNRPEERPT--------------FEYIQSVLDD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLE----------------KKLGAGQ----------------FGEVWMATY--N-------------------------------------KHTKVAVKTMK--PGSMS-----------------------------VEAFLAEANVMKTL--------------------------QHDKLVKLHAVVTKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEFMAK--------------GSLLDFLKS--DEGS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQPLPKLIDFSAQIAEGMAFIEQR---------------------------------------------NYIHRDL-----RAANILVSA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLVCKIADFGLARVIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINF--------------------------------GSFT-IKSDVWSFGILLMEIVTY--G--------------RIPYPG--------------------------------------------------MSNPEVIRALERG--YRMPRPENCP-----------------------------------------------------------------------------------------------------EELYNIMMRCWKNRPEERPT--------------FEYIQSVLDD
Activation segment
DFGLARVIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPE
Binding pocket
KKLGAGQFGEVWMVAVKTMAFLAEANVMKTLQDKLVKLHAVYIITEFMAKGSLLDFLKSFIEQRNYIHRDLRAANILVIADFGLA
Ligand info
Orthosteric ligand
1BM
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2HK5, Chain A