2HEN Chain B
Ephrin type-B receptor 2 (EPHB2)
Inactive — 0.1%DFG-inαC-inATPlike · ADP
Resolution
2.6 Å
R-value
0.205
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms5
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRALAARNILVNSNLVCKVSDFGPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAM
UniProt reference sequence
VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDK
Aligned reference sequence
VKIE----------------QVIGAGE----------------FGEVCSGHL--KLPGK---------------------------------REIFVAIKTLK--SGYTEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNVIHLEGVVTKST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GSLDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLADM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEDDTSD--PTYTSA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MTNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------SALHQLMLDCWQKDRNHRPK--------------FGQIVNTLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------QVIGAGE----------------FGEVCSGHL--KLPGK---------------------------------REIFVAIKTLK--SGYTEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNVIHLEGVVTKST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GSLDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLADM---------------------------------------------NYVHRAL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MTNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------SALHQLMLDCWQKDRNHRPK--------------FGQIVNTLDK
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPE
Binding pocket
QVIGAGEFGEVCSVAIKTLDFLSEASIMGQFDPNVIHLEGVMIITEFMENGSLDSFLRQYLADMNYVHRALAARNILVVSDFG__
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2HEN, Chain B